I wouldn't touch Ekitike. He'll rotate with Isak, both will probably collect decent points but they are not worth the price tags.
Liverpool is without some important players so there is also an option in which Isak takes the striker role and Ekitike plays out wide - not sure you'd want him then.
With all the injuries in Liverpool squad and especially if Szoboszlai is out as well, I think Eketike minutes are now secure. Either on the flank or maybe as a part of diamond shaped 4-4-2 which would be the formation I would use for this LFC side in football manager

Eketike and Isak upfront with Wirtz just behind them.